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Motor response of the human isolated small intestine and urinary bladder to porcine neuromedin U‐8
Author(s) -
Maggi Carlo Alberto,
Patacchini Riccardo,
Giuliani Sandro,
Turini Damiano,
Barbanti Gabriele,
Rovero Paolo,
Meli Alberto
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14675.x
Subject(s) - tetrodotoxin , endocrinology , medicine , ileum , contraction (grammar) , atropine , muscle contraction , biology , urinary bladder , small intestine , chemistry , anatomy
1 Porcine neuromedin U‐8 produced a concentration (0.3 n m −1 μ m )‐dependent contraction of the longitudinal muscle of the human isolated ileum, which was unaffected by either atropine (1 μ m ) or tetrodotoxin (1 μ m ). 2 By contrast, neuromedin U‐8 had only a weak effect on the circular muscle of the human isolated ileum. 3 Neuromedin U‐8 also produced a concentration‐dependent contraction of mucosa‐free muscle strips from the dome of the human isolated urinary bladder, its action being unaffected by either atropine or tetrodotoxin. 4 These findings indicate that neuromedin U‐8 exerts a direct contractile effect on smooth muscle of the human intestinal and urinary tract.