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Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin
Author(s) -
Buckley T.L.,
Brain S.D.,
Williams T.J.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14642.x
Subject(s) - ruthenium red , capsaicin , bradykinin , chemistry , stimulation , vasodilation , calcitonin gene related peptide , histamine , intradermal injection , in vivo , endocrinology , medicine , calcitonin , oligopeptide , pharmacology , calcium , biochemistry , peptide , biology , neuropeptide , receptor , immunology , microbiology and biotechnology , organic chemistry
It has been suggested that ruthenium red has a selective inhibitory effect on capsaicin‐induced nociceptor stimulation. We have investigated the effect of ruthenium red on oedema formation and vasodilatation induced by intradermal (i.d.) injection of capsaicin in the rabbit in vivo . Responses induced by capsaicin were inhibited by ruthenium red, but responses induced by bradykinin, N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP), platelet activating factor (PAF), histamine and calcitonin gene‐related peptide (CGRP) were not affected. These results suggest that ruthenium red selectively inhibits capsaicin‐induced local plasma protein leakage and vasodilatation in the rabbit skin microvasculature.