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Prostanoid stimulation of anion secretion in guinea‐pig gastric and ileal muscosa is mediated by different receptors
Author(s) -
Bunce K.T.,
Spraggs C.F.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14176.x
Subject(s) - prostanoid , gastric mucosa , agonist , medicine , receptor , endocrinology , stimulation , prostaglandin e2 receptor , secretion , intestinal mucosa , prostaglandin , receptor antagonist , chemistry , biology , antagonist , stomach
1 The receptors that mediate stimulation of anion secretion by prostanoids in isolated preparations of guinea‐pig gastric and ileal mucosa have been compared by use of selective prostanoid agonists and antagonists. 2 In gastric mucosa, the relative potency of agonists suggested that the control of anion secretion in this tissue was complex and may be mediated by EP 2 , EP 3 , and TP receptors. A role for TP receptors was confirmed with the TP‐selective antagonist AH23848 which inhibited short circuit current responses to the TP receptor agonist U‐46619 with a pA 2 value of 8.44 but was without effect on responses to prostaglandin E 2 (PGE 2 ) or the EP selective agonist, sulprostone. 3 In ileal mucosa, the relative potency of agonists differed from that observed in gastric mucosa and was consistent with the view that anion secretion in this region of intestine was controlled by DP and EP 2 receptors. 4 These studies suggest that anion secretion in gastric and ileal mucosa is controlled by different prostanoid receptor subtypes and so provide important informtion for the design of prostanoids which may protect gastric mucosa and that are free from side effects such as diarrhoea.