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Effect of intracerebroventricular administration of the GABA B ‐receptor agonist baclofen on operant feeding in satiated pigs
Author(s) -
Ebenezer I.S.,
Baldwin B.A.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14120.x
Subject(s) - baclofen , gabab receptor , agonist , endocrinology , medicine , antagonist , chemistry , food intake , pharmacology , receptor
1 The present study investigated the effects of intracerebroventricular (i.c.v.) administration of the GABA B ‐receptor agonist baclofen on food and water intake in satiated pigs previously trained to make operant responses for food and water, which were available ad libitum . 2 Baclofen (25–100 nmol) i.c.v. produced a dose‐related increase in food intake. Baclofen (50 nmol) increased feeding during the first 15 min after administration ( P > 0.01), while the 100 nmol dose increased feeding during the first 30 min ( P > 0.01). None of these doses of baclofen had any affect on the daily (24 h) food intake. 3 The effect of baclofen (50 nmol) on feeding was prevented by pretreating the animals with the GABA B antagonist phaclofen (500 nmol, i.c.v.). 4 Baclofen (25–100 nmol) i.c.v. had no significant effects on water intake. 5 Intravenous administration of baclofen (100 nmol) had no effect on food intake, thus eliminating the possibility that i.c.v. baclofen might have stimulated feeding by a peripheral mode of action. 6 These results show that baclofen increases food intake in satiated pigs, and that this effect is mediated by the drug acting at central GABA B ‐receptors.