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Induction of non‐specific airway hyperreactivity by potassium channel blockade in rat isolated trachea
Author(s) -
Chand N.,
Diamantis W.,
Sofia R.D.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14117.x
Subject(s) - blockade , potassium channel , medicine , potassium , potassium channel blocker , airway , anesthesia , pharmacology , chemistry , receptor , organic chemistry
1 The exposure of rat isolated tracheal segment to the K + ‐channel inhibitor tetraethylammonium (TEA, 10 m m ) for a period of 10–15 min generally produced little or no contractile response. 2 Cooling (10°C) provocation alone usually produced small (10 ± 3% acetylcholine maximum) contractile responses. 3 In the presence of TEA (10 m m , 10–15 min exposure), rat trachea exhibited airway hyperreactivity to acetylcholine, 5‐hydroxytryptamine (5‐HT) and cooling. It also increased the peak tension induced by 5‐HT. 4 TEA‐induced airway hyperreactivity to cooling was signficantly inhibited in Ca 2+ ‐free Krebs solution suggesting an important role for extracellular Ca 2+ influx. 5 We conclude that the blockade of potassium channels with TEA induces non‐specific airway hyperreactivity to cooling, 5‐HT and acetylcholine in rat isolated tracheal segments.