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Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder
Author(s) -
Mapp Cristina E.,
Chitano Pasquale,
Fabbri Leonardo M.,
Patacchini Riccardo,
Maggi Carlo A.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14109.x
Subject(s) - urinary bladder , pharmacology , chemistry , medicine , urology
1 Toluene diisocyanate produced concentration‐dependent contractions of the rat isolated urinary bladder. 2 The contractions were tetrodotoxin‐resistant and were abolished by previous exposure of the strips to capsaicin. 3 Indomethacin (5 μ m ) and ruthenium red (30 μ m ) inhibited toluene diisocyanate‐induced contractions. Responses expressed as a percentage of the response obtained with substance P, 30 n m , were respectively 141.6 ± 24.8% and 20.1 ± 5.1% in control and indomethacin‐treated strips ( P < 0.005); 123.0 ± 30.2% and 14.0 ± 6.5% in control and ruthenium red‐treated strips (0.01 < P < 0.05). 4 These results suggest that toluene diisocyanate‐induced contractions of the rat isolated bladder are the result of the release of cyclo‐oxygenase products which may act by activating the capsaicin receptor.