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l ‐N G ‐nitro arginine inhibits non‐adrenergic, non‐cholinergic relaxations of guinea‐pig isolated tracheal smooth muscle
Author(s) -
Tucker John F.,
Brave Sandra R.,
Charalambous Litsa,
Hobbs Adrian J.,
Gibson Alan
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14072.x
Subject(s) - cholinergic , guinea pig , adrenergic , smooth muscle , chemistry , parasympathomimetics , acetylcholine , muscle contraction , endocrinology , arginine , pharmacology , medicine , anatomy , biochemistry , muscarinic acetylcholine receptor , amino acid , receptor
The effects of l ‐N G ‐nitro arginine ( l ‐NOARG) on α‐chymotrypsin‐resistant, non‐adrenergic, non‐cholinergic (NANC) relaxations of guinea‐pig tracheal smooth muscle have been examined. l ‐NOARG (1–100 μ m ), but not d ‐NOARG (100 μ m ), inhibited the NANC relaxations in a concentration‐related manner. The effects of l ‐NOARG were partially reversed by l ‐arginine but not d ‐arginine. l ‐NOARG was without effect on acetylcholine‐induced contractile responses of the trachea or on relaxations produced by vasoactive intestinal peptide, sodium nitroprusside or isoprenaline. These results suggest that an endogenous nitrate may contribute to NANC relaxations of tracheal smooth muscle.