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Characterization of cholecystokinin octapeptide‐stimulated endogenous dopamine release from rat nucleus accumbens in vitro
Author(s) -
Marshall F.H.,
Barnes S.,
Pinnock R.D.,
Hughes J.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb13018.x
Subject(s) - nucleus accumbens , dopamine , cholecystokinin , endogeny , in vitro , chemistry , endocrinology , medicine , neuroscience , pharmacology , biology , receptor , biochemistry
1 The effect of cholecystokinin sulphated octapeptide (CCK8S) on endogenous dopamine release was examined in rat striatal and nucleus accumbens slices, by high performance liquid chromatography (h.p.l.c.) with electrochemical detection. 2 CCK8S was shown to increase dopamine release from slices of nucleus accumbens but not striatum in a dose‐dependent manner between 0.1 and 10 μ m . 3 Pentagastrin was without effect on dopamine release at doses up to 10 μ m . 4 The dopamine release produced in the presence of CCK8S was abolished by preincubation of the slice with 1.0 or 10.0 n m L‐364,718 (the CCK A ‐selective antagonist) while 1 μ m L‐365,260 (the CCK B ‐selective antagonist) had no action. 5 These results suggest that the CCK8S‐evoked release of dopamine from the nucleus accumbens is mediated by a CCK A ‐receptor.