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Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations
Author(s) -
Mantelli Laura,
Amerini Sandra,
Ledda Fabrizio
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12995.x
Subject(s) - stimulation , iloprost , arachidonic acid , adrenergic , medicine , endocrinology , prostaglandin e , guinea pig , prostaglandin , chemistry , pharmacology , prostacyclin , receptor , biochemistry , enzyme
1 The effects of prostaglandin E 2 (PGE 2 ) and iloprost on the cardiac response to adrenergic nerve stimulation in guinea‐pig atrial and ventricular preparations have been studied. 2 In guinea‐pig isolated atria both PGE 2 (0.1–10 n m ) and iloprost (0.1–3 μ m ) concentration‐dependently reduced the cardiac response to adrenergic nerve stimulation. 3 The inhibition of cyclo‐oxygenase by indomethacin and acetylsalicylic acid potentiated the response to nerve stimulation in the atrial preparations. 4 Arachidonic acid (1–10 μ m ) reduced the response to nerve stimulation in atria. This effect was prevented by indomethacin and acetylsalicylic acid. 5 In guinea‐pig ventricles PGE 2 and iloprost were found to be effective at higher concentrations than in atrial preparations: arachidonic acid, indomethacin or acetylsalicylic acid did not modify the cardiac response to adrenergic nerve stimulation. 6 These results suggest a different modulator role for endogenous prostaglandins in atrial and ventricular tissue.