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Effects of antiarrhythmic agents classified as class III group on ischaemia‐induced myocardial damage in canine hearts
Author(s) -
Sano T.,
Sugiyama S.,
Taki K.,
Hanaki Y.,
Shimada Y.,
Ozawa T.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12971.x
Subject(s) - amiodarone , sotalol , medicine , cardiology , ischemia , antiarrhythmic agent , anti arrhythmia agents , anesthesia , pharmacology , heart disease , atrial fibrillation
1 The cardioprotective effects of antiarrhythmic agents classified as class III, amiodarone, sotalol and E‐4031, were investigated in anaesthetized dogs. 2 The left anterior descending coronary artery was occluded for 2 h. 3 Heart mitochondria were prepared from both the ischaemic and non‐ischaemic areas, and their function was estimated polarographically. 4 Activities of the lysosmal enzymes, N‐acetyl‐β‐glucosaminidase and β‐glucuronidase, were measured in each fraction. 5 Two hour occlusion induced ventricular arrhythmias, and amiodarone, sotalol and E‐4031 greatly suppressed the development of arrhythmias. 6 Amiodarone, sotalol and E‐4031 significantly protected mitochondria against ischaemia, and prevented ischaemia‐induced leakage of lysosomal enzymes. 7 Antiarrhythmic agents classified as class III show cardioprotective effects, which might participate in their antiarrhythmic effect.