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Role of endothelium and calcium channels in endothelin‐induced contraction of human cerebral arteries
Author(s) -
Aguilera E. Martín,
Irurzun A.,
Vila J.M.,
Aldasoro M.,
Galeote M.S.,
Lluch S.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12945.x
Subject(s) - nicardipine , cerebral arteries , endothelin receptor , contraction (grammar) , calcium , endothelium , medicine , endocrinology , endothelin 1 , extracellular , chemistry , biology , biochemistry , receptor
Endothelin constricted human isolated cerebral arteries in a concentration‐dependent manner. The maximal tension developed, as well as EC 50 values were similar in arteries with and without endothelium. Removal of extracellular calcium or addition of the calcium antagonist nicardipine (10 −6 m ), attenuated but did not abolish responses to endothelin. These experiments show that the endothelin‐induced contraction in human cerebral arteries is not linked to the presence of intact endothelial cells. The data also show that the contractile effects of endothelin cannot be explained solely by an action on voltage‐dependent calcium channels.