Premium
Inability of endothelin to increase Ca 2+ current in guinea‐pig heart cells
Author(s) -
Tohse Noritsugu,
Hattori Yuichi,
Nakaya Haruaki,
Endou Masayuki,
Kanno Morio
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12944.x
Subject(s) - medicine , inotrope , contractility , endocrinology , endothelin 1 , endothelin receptor , myocyte , endoplasmic reticulum , ryanodine receptor , guinea pig , sarcolemma , endothelins , biology , chemistry , calcium , microbiology and biotechnology , receptor
Effects of endothelin, a novel vasoconstrictor peptide derived from vascular endothelial cells, on cardiac contractility and membrane currents, were examined in guinea‐pig cardiac preparations. Endothelin (3–1000 n m ) produced a positive inotropic effect in papillary muscles in a concentration‐dependent manner. In whole‐cell voltage clamp recording, endothelin (250 n m ) decreased the amplitude of Ca 2+ current (I Ca , 25.0 ± 6.6%) in ventricular myocytes. The endothelin‐induced decrease in I Ca was abolished by pretreatment with ryanodine (1 μ m ). These results suggest that endothelin does not activate cardiac sarcolemmal Ca 2+ channels. The enhancement of the sarcoplasmic reticulum function may play an important role in the positive inotropic effect of endothelin.