Premium
Inhibitory effect of streptozotocin‐induced diabetes on non‐cholinergic motor transmission in rat detrusor and its prevention by sorbinil
Author(s) -
Luheshi G.N.,
Zar M.A.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12723.x
Subject(s) - sorbinil , endocrinology , detrusor muscle , medicine , carbachol , streptozotocin , cholinergic , aldose reductase inhibitor , diabetes mellitus , acetylcholine , stimulation , urinary bladder , pyridostigmine bromide , aldose reductase , pyridostigmine , myasthenia gravis
1 Non‐cholinergic motor transmission in the urinary bladder of streptozotocin (STZ)‐diabetic rats was studied by recording contractile activity of strips of detrusor in vitro . 2 The neurogenic contractile responses to electrical field stimulation (EFS) of atropine‐treated detrusor strips were decreased in 4, 8 and 12 week STZ‐diabetic rats. The decrease was most marked in 12 week diabetic rats and least in 4 week ones. 3 Concentration‐response curves showed no change in sensitivity of the detrusor to acetylcholine (ACh) in diabetic rats. The maximum tension generated by ACh was similar in diabetic and non‐diabetic animals. 4 The contractile responses to EFS at frequencies ≥ 1 Hz were not maintained during stimulation. The ‘fade’ was significantly greater in detrusor strips of diabetic rats. 5 The contractile response of detrusor to EFS was significantly greater in 12 week diabetic rats treated with the aldose reductase inhibitor sorbinil, than in untreated 12 week diabetic rats. The sensitivity to ACh was similar in the two groups. 6 It is concluded that the reduction of the neurogenic non‐cholinergic responses of detrusor to EFS in STZ‐diabetic rats is probably caused by a reduction in the release of the non‐cholinergic motor transmitter. The results are discussed in relation to bladder dysfunction in human diabetes mellitus.