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Inhibitory actions of prostaglandin E 1 on non‐adrenergic non‐cholinergic contraction in guinea‐pig bronchi
Author(s) -
Aikawa Takashi,
Sekizawa Kiyohisa,
Itabashi Shigeru,
Sasaki Hidetada,
Takishima Tamotsu
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12080.x
Subject(s) - contraction (grammar) , guinea pig , adrenergic , cholinergic , muscle contraction , inhibitory postsynaptic potential , endocrinology , medicine , chemistry , parasympathomimetics , sympathomimetics , pharmacology , muscarinic acetylcholine receptor , receptor
We have investigated the effect of prostaglandin E 1 (PGE 1 ) on non‐adrenergic, non‐cholinergic (NANC) contraction in guinea‐pig bronchial strips. PGE 1 (10 nM to 10 μ m ) did not alter baseline tension but reduced NANC contractions induced by electrical field stimulation (EFS) in a concentration‐dependent fashion (‐log EC 50 was 6.60 ± 0.10M and maximum inhibition was 88.7 ± 2.9%). PGE 1 (>0.3 μ m ) also reduced the contraction induced by substance P (1 μ m ). Removal of epithelium did not alter the effects of PGE 1 on NANC contraction. These results suggest that PGE 1 exerts both pre‐ and post‐junctional inhibitory actions on NANC contraction.