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Potassium‐stimulated release of nitric oxide from cerebellar slices
Author(s) -
Dickie B.G.M.,
Lewis M.J.,
Davies J.A.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12078.x
Subject(s) - nitric oxide , glutamate receptor , cyclic guanosine monophosphate , guanosine , potassium , chemistry , stimulation , cyclic gmp , cerebellum , endogeny , biophysics , medicine , biochemistry , biology , receptor , organic chemistry
This study shows that nitric oxide release can be evoked from intact neuronal tissue. Stimulation of rat cerebellar slices for 4 min with 50 mM potassium significantly increased the release of nitric oxide and glutamate and was associated with a rise in the guanosine 3′:5′‐cyclic monophosphate (cyclic GMP) content of the tissue. Nitric oxide levels in the perfusate increased from 160 to 262 parts per billion. It is suggested that an increased release of endogenous glutamate in the slice, induced by exposure to potassium, may mediate the release of nitric oxide.