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Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine
Author(s) -
Kendall D.A.,
Firth J.L.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb12048.x
Subject(s) - histamine , adenosine , inositol , carbachol , theophylline , chemistry , phospholipid , inositol phosphate , inositol trisphosphate , medicine , hydrolysis , endocrinology , biochemistry , biology , receptor , membrane
1 Inositol phospholipid hydrolysis was examined in human cerebral cortex slices by a [ 3 H]‐inositol prelabelling assay. 2 Enhancement of [ 3 H]‐inositol phosphates accumulation was observed in the presence of carbachol, noradrenaline, histamine, 5‐hydroxytryptamine (5‐HT) and depolarizing concentrations of KCl. 3 Despite having no effect alone, adenosine (and its analogue 2‐chloroadenosine) selectively inhibited the direct response to histamine. 4 The inhibition due to adenosine was antagonized by theophylline, but not by 8‐cyclopropyltheophylline.