Premium
Arachidonic acid‐induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin‐sensitive structures
Author(s) -
Manzini Stefano,
Ballati Lido,
Geppetti Pierangelo,
Rubini Ilaria,
Meini Stefania,
Perretti Francesca
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12649.x
Subject(s) - capsaicin , neuropeptide , arachidonic acid , sensory system , chemistry , neuroscience , biophysics , biology , biochemistry , receptor , enzyme
Administration of arachidonic acid (AA) both in vitro and in vivo elicited prominent contractile responses in guinea‐pig airways, which were markedly reduced after capsaicin desensitization. Furthermore, AA superfusion elicited a significant calcitonin gene‐related peptide‐like immunoreactivity release from isolated bronchi. It is suggested that at least part of the bronchomotor actions of AA rely upon stimulation of capsaicin‐sensitive primary afferents.