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Functional role of cholinoceptors and purinoceptors in human isolated atrial and ventricular heart muscle
Author(s) -
Jakob Helga,
Oelert Hellmut,
Rupp Johanna,
Nawrath Hermann
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12579.x
Subject(s) - mammalian heart , medicine , human heart , purinergic receptor , cardiovascular physiology , autonomic nervous system , cardiology , circulatory system , neuroscience , biology , heart rate , receptor , blood pressure
1 The effects of cholinergic and purinergic stimulation on action potential, force of contraction and 86 Rb efflux were investigated in human atrial and ventricular heart muscle. 2 In atrial heart muscle, carbachol and (−)‐N 6 ‐(R‐phenyl‐isopropyl)‐adenosine (R‐PIA) and 5′‐(N‐ethyl)‐carboxamido‐adenosine (NECA) evoked transient decreases of action potential duration and force of contraction; the steady‐state effects on force of contraction were virtually identical to control values. In the presence of propranolol, steady‐state values after carbachol, R‐PIA or NECA amounted to about 50% of control values. 3 In ventricular heart muscle, carbachol, NECA and R‐PIA did not significantly affect the action potential configuration or force of contraction. 4 Carbachol, NECA and R‐PIA induced a maintained depression of the positive inotropic response to isoprenaline in both atrial and ventricular heart muscle. 5 The rate constant of 86 Rb efflux was slightly increased by carbachol, NECA and R‐PIA in atrial (10–20%) but not in ventricular heart muscle. 6 In the presence of isoprenaline, carbachol, NECA and R‐PIA did not significantly affect the rate constant of 86 Rb efflux in both atrial and ventricular heart muscle. Isoprenaline alone increased the rate constant of 86 Rb by about 25% in both tissues.