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Effects of α‐ and β‐calcitonin gene‐related peptides upon ion transport in rat descending colon
Author(s) -
Cox H.M.,
Ferrar J.A.,
Cuthbert A.W.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12553.x
Subject(s) - calcitonin gene related peptide , tetrodotoxin , calcitonin , medicine , endocrinology , mediator , somatostatin , chemistry , peptide , neuropeptide , biology , biochemistry , receptor
Both α‐ and β‐calcitonin gene‐related peptide (CGRP) exhibit concentration‐dependent dual actions upon rat colonic epithelia. At low concentrations (i.e. 0.03–10 n m ) both CGRPs produce antisecretory effects that are abolished by pretreating tissues with tetrodotoxin (TTX). At higher concentrations (30–200 n m ) secretory responses predominate and these effects are not abolished by TTX. It is suggested that the mediator of the antisecretory actions of CGRPs is somatostatin.