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Streptozotocin‐induced diabetes reduces the density of [ 125 I]‐endothelin‐binding sites in rat cardiac membranes
Author(s) -
Nayler Winifred G.,
Liu Jianjun,
Panagiotopoulos Sianna,
Casley David J.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12552.x
Subject(s) - streptozotocin , membrane , medicine , endocrinology , diabetes mellitus , selectivity , chemistry , binding site , endothelin 1 , biophysics , biology , biochemistry , receptor , catalysis
The effect of acute, streptozotocin‐induced diabetes on the affinity ( K D ), density ( B max ) and selectivity of specific, high affinity binding sites for [ 125 I]‐endothelin ([ 125 I]‐ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg −1 ), the density of [ 125 I]‐ET binding sites was reduced ( P < 0.01) without changes in affinity or selectivity.