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Endothelin‐ and neuropeptide Y‐induced vasoconstriction of human epicardial coronary arteries in vitro
Author(s) -
FrancoCereceda Anders
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12038.x
Subject(s) - vasoconstriction , neuropeptide y receptor , endothelin receptor , coronary arteries , medicine , endothelin 1 , vasoconstrictor agents , endocrinology , endothelium , circulatory system , neuropeptide , artery , cardiology , receptor
1 The effects of the recently discovered peptide endothelin and neuropeptide Y (NPY) on human epicardial coronary arteries were studied in vitro . 2 Endothelin induced a concentration‐dependent, endothelium‐independent, long‐lasting vasoconstriction regardless of vessel size. NPY evoked contractions of small coronary arteries with a similar potency to that of endothelin, although to a significantly lower degree. Large coronary arteries did not respond to NPY. Endothelin did not relax coronary arteries precontracted with potassium. 3 The effect of endothelin was dependent on extracellular Ca 2+ and, like NPY, significantly reduced by the Ca 2+ ‐antagonist nifiedipine. 4 In conclusion, endothelin is a potent human vasoconstrictor in vitro . It is suggested that endothelin may be involved in the regulation of coronary blood flow.