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The action of dopamine and vascular dopamine (DA 1 ) receptor agonists on human isolated subcutaneous and omental small arteries
Author(s) -
Hughes A.D.,
Sever P.S.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12036.x
Subject(s) - fenoldopam , dopamine , sulpiride , endocrinology , medicine , phentolamine , sch 23390 , myograph , dopamine receptor , chemistry , dopamine agonist , agonist , dopaminergic , receptor , contraction (grammar)
1 Human small arteries were obtained from surgical specimens and studied in vitro by use of a myograph technique. Following induction of tone with a potassium depolarizing solution, dopamine in the presence of β‐adrenoceptor and catecholamine uptake blockade relaxed isolated omental and subcutaneous arteries. Preincubation of tissues with phentolamine increased the maximum relaxation in response to dopamine. 2 The selective vascular dopamine receptor agonists, fenoldopam and SKF 38393 also relaxed isolated subcutaneous and omental arteries in a concentration‐dependent manner. The order of potency for agonists was dopamine > fenoldopam > SKF 38393. 3 Dopamine‐induced relaxation was competitively antagonized by SCH 23390, (R)− and (S)‐sulpiride, and fenoldopam induced relaxation by SCH 23390 and (+)− but not (−)‐butaclamol. 4 These results indicate the presence of vascular dopamine receptors (DA 1 subtype) on human isolated resistance arteries from omental and subcutaneous sites.