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Effect of chronic intra‐accumbens administration of the TRH analogue CG3509 on histamine‐induced behaviour in the rat
Author(s) -
Bristow L.J.,
Bennett G.W.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12012.x
Subject(s) - nucleus accumbens , histamine , endocrinology , medicine , neuropeptide , dopamine , thyrotropin releasing hormone , chemistry , receptor , hormone
1 The present study has investigated the effect of chronic intra‐accumbens administration of the thyrotrophin‐releasing hormone (TRH) analogue, CG3509, on CG3509‐ and histamine‐induced spontaneous motor activity and brain TRH‐like immunoreactive (TRH‐LI) levels in the rat. 2 Chronic intra‐accumbens administration of CG3509 (5 × 5 μg over 3 days) induced: (a) a significant (P <0.05) reduction in intra‐accumbens CG3509 (0.5 μg)‐induced hyperactivity, (b) reduced levels of TRH‐LI in the nucleus accumbens but not other brain regions, (c) a marked increase (107%, P < 0.01) in histamine‐induced non‐locomotor hyperactivity. 3 The present results demonstrate that alteration of central TRH function following treatment with a TRH analogue enhances the effect of intra‐accumbens histamine on behavioural hyperactivity, possibly via changes in H 1 receptors and suggest that the neuropeptide, TRH and histamine interact in behavioural arousal mechanisms in rat brain.