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The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin
Author(s) -
Dixon E.J.A.,
Wilsoncroft P.,
Robertson D.N.,
Page C.P.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb12008.x
Subject(s) - propranolol , bronchial hyperresponsiveness , platelet activating factor , histamine , guinea pig , pharmacology , antagonist , acetylcholine , medicine , chemistry , endocrinology , respiratory disease , receptor , lung
1 Intravenous administration of platelet activating factor, Paf (600 ng kg −1 h −1 ) to ventilated anaesthetised guinea‐pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2 Pretreatment of ventilated, anaesthetised guinea‐pigs with the β‐adrenoceptor antagonist, propranolol, or the non‐steroidal anti‐inflammatory drug, indomethacin, induced bronchial hyperresponsiveness to i.v. histamine. 3 Paf‐induced bronchial hyperresponsiveness was significantly attenuated by pretreatment with three different Paf antagonists, CV‐3988, BN 52021 and WEB 2086. 4 Pretreatment of guinea‐pigs with CV‐3988, BN 52021 or WEB 2086 at doses inhibiting Paf‐induced bronchial hyperresponsiveness, had no significant effect on propranolol or indomethacin‐induced bronchial hyperresponsiveness. 5 It is suggested that bronchial hyperresponsiveness induced by propranolol or indomethacin is not secondary to Paf release in the guinea‐pig.