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Endothelium‐derived relaxing factor is an endogenous vasodilator in man
Author(s) -
Collier Joe,
Vallance Patrick
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11998.x
Subject(s) - dilator , vasoconstriction , endothelium derived relaxing factor , vasodilation , acetylcholine , endothelium , medicine , prostacyclin , endogeny , endocrinology , cardiology , anesthesia
Removal of venous endothelium in man leads to vasoconstriction and loss of dilator response to acetylcholine but not to glyceryl trinitrate. This pattern of responses can be accounted for by loss of endotheliumderived relaxing factor (EDRF), but not by loss of prostacyclin. This provides the first direct evidence for endothelium‐dependent dilatation in man in vivo , and suggests that basal release of EDRF is a determinant of resting venous tone.