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Negative inotropic activity of antilaminin IgG: participation of cholinergic mechanisms
Author(s) -
Bacman Sandra,
Borda Enri,
Denduchis Berta,
Lustig Livia,
SterinBorda Leonor
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11964.x
Subject(s) - cholinergic , muscarinic acetylcholine receptor , inotrope , acetylcholine , antihistamine , medicine , endocrinology , terfenadine , pyrilamine , carbachol , mepyramine , tetrodotoxin , nicotinic agonist , diphenhydramine , oxotremorine , hexamethonium , atropine , chemistry , histamine , biology , pharmacology , antagonist , receptor
1 Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non‐competitive fashion. 2 Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse isolated atria. Hemicholinium and tetrodotoxin also reduced the response while the antihistamine, pyrilamine was without effect. 3 These results suggest that antilaminin IgG modulates cholinergic function in mouse isolated atria. Possible mechanisms are discussed.