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Vasoactive actions of local anaesthetics on human isolated umbilical veins and arteries
Author(s) -
Monuszko Eileen,
Halevy Simon,
Freese Kenneth,
LiuBarnett Maida,
Altura Burton
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11957.x
Subject(s) - contraction (grammar) , bupivacaine , anesthesia , medicine , muscle contraction , vasoactive , muscle relaxation , tachyphylaxis , chemistry , anatomy
1 An in vitro study, using helical preparations of human umbilical arteries and veins obtained from healthy women at term pregnancy, was designed to determine: (a) whether three local anaesthetics commonly utilized in obstetric anaesthesia (bupivacaine, 2‐chloroprocaine, and lignocaine) can induce contraction or relaxation of resting umbilical vessels; (b) whether these agents can induce contraction or relaxation of umbilical vessels which have been previously induced to contract by a known activator, potassium chloride (KCl); and (c) the relative potency of these agents as compared to KCl. 2 The results indicate that: (a) these local anaesthetics are vasoactive on human umbilical vascular smooth muscle; (b) bupivacaine induces contraction in over 90% of the resting vessels examined, while 2‐chloroprocaine consistently causes relaxation and lignocaine causes a small degree of contraction in 40% of vessels examined; (c) bupivacaine causes further contraction (or potentiation) of KCl‐contracted muscle in 50% of the vessels studied, while 2‐chloroprocaine and lignocaine both induce relaxation of these contracted vessels.