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Involvement of a pertussis toxin‐sensitive G‐protein in the pharmacological properties of septo‐hippocampal neurones
Author(s) -
Rascol Olivier,
Dutar Patrick,
Lamour Yvon
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11907.x
Subject(s) - pertussis toxin , hippocampal formation , carbachol , excitatory postsynaptic potential , gabaa receptor , inhibitory postsynaptic potential , gabab receptor , medicine , endocrinology , chemistry , receptor , acetylcholine , baclofen , picrotoxin , hippocampus , neuroscience , g protein , pharmacology , biology , agonist
1 The physiological and pharmacological properties of identified septo‐hippocampal neurones (SHNs) have been studied in rats pretreated with the bacterial toxin, pertussis toxin (PTX). 2 In rats anaesthetized with urethane and pretreated with PTX, the axonal conduction velocity was unchanged while the mean spontaneous activity was significantly increased. 3 PTX pretreatment had no effect on responses of SHNs to the iontophoretic application of γ‐aminobutyric acid (GABA) and cholinoceptor agonists (acetylcholine or carbachol). 4 Baclofen and 5‐hydroxytryptamine (5‐HT), almost exclusively inhibitory in control rats, had little effect or an excitatory effect in PTX pretreated rats. 5 These results suggest the involvement of a pertussis toxin‐sensitive G‐protein in responses mediated by 5‐HT and GABA B ‐receptors but not in responses mediated by cholinoceptors and GABA A ‐receptors in medial septum neurones projecting into the hippocampus.