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Castor oil increases intestinal formation of platelet‐activating factor and acid phosphatase release in the rat
Author(s) -
Pinto A.,
Calignano A.,
Mascolo N.,
Autore G.,
Capasso F.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11897.x
Subject(s) - platelet activating factor , jejunum , castor oil , duodenum , ileum , alkaline phosphatase , medicine , endocrinology , chemistry , biochemistry , biology , enzyme
1 When castor oil was administered by gavage to rats, the duodenum and jejunum but not ileum and colon produced large amounts (5–6 fold greater than control) of platelet activating factor (Paf). 2 Intraluminal release of acid phosphatase (AP) was also markedly increased (5–6 fold greater than control) in the duodenum and jejunum of castor oil‐treated rats and there was a correlation between the elevated release of AP and intestinal hyperaemia. 3 These findings support a role for Paf as a mediator of intestinal damage induced by castor oil.