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Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol‐sensitive
Author(s) -
Maltin C.A.,
Hay S.M.,
Delday M.I.,
Reeds P.J.,
Palmer R.M.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11889.x
Subject(s) - clenbuterol , propranolol , endocrinology , medicine , soleus muscle , antagonist , agonist , chemistry , skeletal muscle , denervation , receptor
1 The effect of propranolol on the clenbuterol‐induced protein anabolism in innervated and denervated soleus and plantaris muscles of the rat was studied. 2 The response to the β‐agonist, clenbuterol, in both innervated and denervated muscles, was not significantly inhibited by the β‐antagonist, propranolol. 3 The results provide further evidence to suggest that the action of clenbuterol on skeletal muscle protein accretion may not be directly mediated by β‐adrenoceptors.