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Noradrenaline (gamma) and ATP responses of innervated and non‐innervated rat cerebral arteries
Author(s) -
Edwards F.R.,
Hards Daphne,
Hirst G.D.S.,
Silverberg G.D.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11884.x
Subject(s) - cerebral arteries , adrenergic , anatomy , middle cerebral artery , artery , cerebral circulation , circulatory system , medicine , adrenergic receptor , norepinephrine , biology , endocrinology , dopamine , receptor , ischemia
1 The distribution of sympathetic adrenergic nerves on the rat middle cerebral artery and on the arterioles which originated from it was determined by use of gloxylic histochemistry. 2 Whereas the middle cerebral artery and proximal arterioles arising from this artery received a sympathetic innervation, the distal regions of the same arterioles were devoid of innervation. 3 The arteries and arterioles which were innervated were depolarized by noradrenaline in the combined presence of α‐ and β‐adrenoceptor antagonists. Those which were not innervated were not depolarized by noradrenaline. 4 ATP depolarized all arteries and arterioles examined. 5 These observations are discussed with respect to the similarities and differences between γ‐adrenoceptors and P 2 purinoceptors.