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Potent contractile activity of endothelin on the human isolated urinary bladder
Author(s) -
Maggi Carlo Alberto,
Giuliani Sandro,
Patacchini Riccardo,
Santicioli Paolo,
Turini Damiano,
Barbanti Gabriele,
Meli Alberto
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11879.x
Subject(s) - carbachol , nifedipine , contraction (grammar) , endothelin receptor , endocrinology , muscle contraction , medicine , chemistry , urinary bladder , detrusor muscle , endothelin 1 , atropine , calcium , smooth muscle , endothelins , biology , stimulation , receptor
Endothelin (1 n m ‐0.3μ m ) produced a concentration‐related contraction of mucosa‐free muscle strips excised from the dome of the human urinary bladder. The response to endothelin was unaffected by either atropine (1 μ m ) or nifedipine (1 μ m ) at concentrations that abolished the response to carbachol and KCl, respectively. These findings indicate that mechanisms other than activation of dihydropyridine‐ and voltage‐sensitive calcium channels may be involved in the action of endothelin on smooth muscles.