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Acute stress and GABAergic function in the rat brain
Author(s) -
Losada Matilde E. Otero
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11846.x
Subject(s) - neurochemical , gabaergic , endocrinology , medicine , gaba transaminase , striatum , piriform cortex , gamma aminobutyric acid , glutamate decarboxylase , glutamate receptor , chemistry , hypothalamus , olfactory bulb , neuroscience , hippocampus , olfactory system , biology , dopamine , central nervous system , biochemistry , inhibitory postsynaptic potential , enzyme , receptor
1 The function of the γ‐aminobutyric acid (GABA)‐ergic system in certain areas of the rat brain was investigated after acute (5 min) exposure to immobilization stress. 2 The activities of glutamate decarboxylase and GABA‐transaminase, GABA concentrations, GABA turnover in vivo and uptake of [ 3 H]‐GABA were measured. 3 After 5 min of immobilization stress, GABA concentrations and [ 3 H]‐GABA uptake were reduced, and GABA turnover stimulated in the olfactory bulbs. In contrast the uptake of [ 3 H]‐GABA was increased in the corpus striatum after 5 min of immobilization stress. 4 None of the parameters measured was significantly altered by acute immobilization stress in the frontal cortex, hippocampus or medio‐basal hypothalamus. 5 These findings show that the olfactory bulbs and the corpus striatum are sensitive to the effects of acute stress. Since GABA in the olfactory bulbs is involved in the development of aggression and increased emotional state, it follows that neurochemical changes induced by acute stress might underlie some behavioural manifestations observed after stress.