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Neurotransmission in pig renal artery: the actions of angiotensin II and dopamine
Author(s) -
Ferguson D.R.,
Randall M.D.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11814.x
Subject(s) - sulpiride , dopamine , medicine , endocrinology , angiotensin ii , chemistry , stimulation , renal artery , neurotransmission , dopamine receptor , receptor , kidney , dopaminergic
1 Electrical stimulation of pig renal arteries causes contractions which are potentiated in the presence of angiotensin II (5 × 10 −8 m ). 2 The potentiation is followed by a long‐lasting inhibitory phase which is mimicked by dopamine and 2‐amino‐6,7,dihydroxy‐1,2,3,4,‐tetrahydronaphthalene (ADTN), but blocked by sulpiride (5 × 10 −8 m ). 3 Release of noradrenaline from renal artery rings by 25 mM K + was measured by h.p.l.c. and found to be increased by 5 × 10 −8 m angiotensin II. As this was done in the presence of 1 × 10 −6 m desmethylimipramine it was concluded that the increase was due to increased neuronal release of noradrenaline, not inhibition of neuronal uptake. 4 The experiments indicate that dopamine is present in the artery wall and produces its effects through DA 2 ‐receptors.