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Expression of functional postjunctional α 2 ‐adrenoceptors in rabbit isolated distal saphenous artery—a permissive role for angiotensin II?
Author(s) -
Dunn W.R.,
McGrath J.C.,
Wilson V.G.
Publication year - 1989
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1989.tb11810.x
Subject(s) - angiotensin ii , medicine , adrenergic , endocrinology , renin–angiotensin system , anatomy , biology , chemistry , receptor , blood pressure
In the rabbit isolated distal saphenous artery, the population of postjunctional adrenoceptors is of the α 1 variety under normal in vitro experimental conditions, based on the potency order of selective agonists and on the effects of the antagonists prazosin and rauwolscine against responses to UK‐14304. Angiotensin II (AII, 0.05 μ m ) however, without affecting resting baseline tension, markedly enhanced responses to UK‐14304, particularly at low concentrations. This previously unseen component of the response to UK‐14304 was resistant to prazosin (0.1 μ m ) but susceptible to rauwolscine (1 μ m ). AII would therefore appear to have a permissive role for the expression of a quiescent population of postjunctional α 2 ‐adrenoceptors in the rabbit distal saphenous artery.