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A 5‐HT 1 ‐like receptor mediates a pertussis toxin‐sensitive inhibition of rat ventromedial hypothalamic neurones in vitro
Author(s) -
Newberry Nigel R.,
Priestley Tony
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb16541.x
Subject(s) - pertussis toxin , ketanserin , spiperone , 5 ht receptor , receptor , agonist , endocrinology , medicine , pharmacology , in vitro , toxin , biology , serotonin , chemistry , g protein , biochemistry
5‐ Hydroxytryptamine (5‐HT), 5‐carboxamidotryptamine and 8‐hydroxy‐2‐(di‐n‐propylamino)‐tetralin inhibited rat ventromedial hypothalamic neurones in vitro in a concentration‐dependent manner. The agonist‐induced inhibition was reduced by spiperone (1 μ M ) and by pertussis toxin, but not by MDL 72222 (10 μ M ) or ketanserin (1 μ M ). The inhibition appeared to be mediated via 5‐HT 1A ‐receptors and a pertussis toxin‐sensitive pathway.