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Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo
Author(s) -
Öhlén Anders,
Wiklund N. Peter,
Persson Magnus G.,
Hedqvist Per
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11691.x
Subject(s) - calcitonin gene related peptide , substance p , medicine , endocrinology , in vivo , calcitonin , chemistry , skeletal muscle , neuropeptide , receptor , biology , microbiology and biotechnology
Calcitonin gene‐related peptide (CGRP) was tested for possible interactions with the effects of substance P on rabbit skeletal muscle arterioles in vivo . Both CGRP and substance P dose‐dependently increased arteriolar diameter. However, pretreatment with CGRP made the arterioles insensitive to substance P, and also prevented the formation of aggregates of leukocytes and platelets normally seen after substance P. These results suggest that CGRP, in addition to its direct effects, may act as a modulator of the effects of substance P in neurogenic inflammation.