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Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists
Author(s) -
Shaw John S.,
Rourke Janet D.,
Burns Karen M.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11679.x
Subject(s) - agonist , nociception , antagonist , partial agonist , pharmacology , opioid , chemistry , ed50 , tail flick test , constriction , medicine , anesthesia , receptor
1 The antinociceptive activity of a range of opioid agonists and agonist‐antagonist analgesics was determined in mice by use of the 55°C hot plate and abdominal constriction assays. 2 Opioid agonists were approximately 10 times more effective in the abdominal constriction assay. 3 The agonist‐antagonists produced analgesia only in the abdominal constriction assay, and antagonized the antinociceptive action of opioid agonists in the 55°C hot plate test. 4 These differences were shown to be attributable to the different levels of stimulus employed in the two tests. 5 By comparing the antagonist potencies of the agonist‐antagonists in the 55°C hot plate test with their antinociceptive ED 50 values in the abdominal constriction assay, an index of intrinsic activity was calculated.