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A calcium‐dependent rather than a G‐protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine
Author(s) -
Lim S.P.,
Bolton T.B.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11649.x
Subject(s) - muscarinic acetylcholine receptor , stimulation , calcium , chemistry , receptor , biophysics , endocrinology , medicine , muscarinic acetylcholine receptor m3 , biology , microbiology and biotechnology , biochemistry
A role of internal calcium was found in the inward current response of single, dispersed, smooth muscle cells to muscarinic receptor activation but no obligatory role for guanine nucleotide binding proteins, in contrast to their obligatory role in muscarinic responses in heart and other tissues.