Premium
The actions of neuropeptide Y and peptide YY on the hepatic arterial and portal vascular beds of the anaesthetized dog
Author(s) -
Corder R.,
Withrington P.G.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11633.x
Subject(s) - peptide yy , neuropeptide y receptor , neuropeptide , medicine , endocrinology , chemistry , receptor
1 The vascular actions of the two peptides, neuropeptide Y (NPY) and peptide YY (PYY) were compared with the transmitter noradrenaline (NA) on the arterial and portal vascular beds of the in situ liver of the anaesthetized dog. 2 The sole vascular response of the hepatic arterial vasculature to intra‐arterial administration of either NPY or PYY was vasoconstriction; the duration of these responses was longer than that to NA. 3 The maximum hepatic arterial vasoconstrictor responses to PYY and to NPY were significantly different and they were both significantly less than the maximum to NA ( P > 0.001). 4 In contrast to its activity on the splenic arterial vasculature PYY was not more potent, on a molar basis, than NPY as an hepatic arterial vasoconstrictor agent. However, both peptides were significantly more potent than NA ( P > 0.005). 5 Neither peptide, when injected intraportally, caused any change in intrahepatic portal inflow resistance. 6 Both peptides when administered intraportally in doses which were free of systemic effects caused hepatic arterial vasoconstriction.