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In vivo EDRF activity influences platelet function
Author(s) -
Hogan J.C.,
Lewis M.J.,
Henderson A.H.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11616.x
Subject(s) - endothelium derived relaxing factor , in vivo , carbachol , methylene blue , chemistry , platelet , pharmacology , platelet adhesiveness , cyclic gmp , biological activity , endocrinology , medicine , in vitro , platelet aggregation , biochemistry , biology , enzyme , receptor , microbiology and biotechnology , photocatalysis , catalysis
The administration of carbachol to rabbits to stimulate the release of endothelium derived relaxing factor (EDRF) results in inhibition of platelet aggregation and elevation of platelet cyclic GMP content. These effects are reversed by simultaneous administration of the EDRF inhibitors methylene blue or haemoglobin. The data provide the first direct biochemical evidence of in vivo EDRF activity.