Premium
Actions of dopamine antagonists on stimulated striatal and limbic dopamine release: an in vivo voltammetric study
Author(s) -
Stamford Jonathan A.,
Kruk Zygmunt L.,
Millar Julian
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11605.x
Subject(s) - dopamine , nucleus accumbens , dopamine receptor d2 , striatum , chemistry , limbic system , endocrinology , medicine , autoreceptor , dopamine receptor d1 , pharmacology , neuroscience , antagonist , biology , receptor , central nervous system
1 Fast cyclic voltammetry at carbon fibre microelectrodes was used to study the effects of several dopamine antagonists upon stimulated dopamine release in the rat striatum and nucleus accumbens. 2 In both nuclei, stimulated dopamine release was increased by D 2 ‐receptor‐selective and mixed D 1 /D 2 ‐receptor antagonists. The D 1 ‐selective antagonist SCH 23390 had no effect. 3 Striatal and limbic dopamine release were elevated by cis ‐ but not trans ‐flupenthixol. 4 The ‘atypical’ neuroleptics (clozapine and thioridazine) did not cause a selective elevation of dopamine release in the limbic terminal region, whereas the non‐antipsychotic drug metoclopramide increased dopamine release more in striatum than nucleus accumbens. 5 We conclude from this study that striatal and limbic dopamine release are under the control of a stereoselective dopamine D 2 ‐autoreceptor on the nerve terminal and that atypical neuroleptics do not show a limbic‐selective effect at this receptor after acute administration.