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Involvement of central α‐ and β‐adrenoceptors in the pressor response to electrical stimulation of the rostral ventrolateral medulla in rats
Author(s) -
WardRoutledge C.,
Marshall P.,
Marsden C.A.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11567.x
Subject(s) - stimulation , atenolol , antagonist , idazoxan , medicine , endocrinology , rostral ventrolateral medulla , hypothalamus , propranolol , medulla , medulla oblongata , chemistry , prazosin , receptor , central nervous system , blood pressure
1 Electrical stimulation of the C 1 area of the rostral ventrolateral medulla in rats elicits an increase in mean arterial pressure (MAP). 2 This increase in MAP is attenuated by intra‐hypothalamic and intradsternal administration of the non‐selective β‐adrenoceptor antagonist (±)‐propranolol and the β 2 ‐selective antagonist ICI 118551. 3 The selective β 1 ‐antagonist atenolol and (+)‐propranolol, which is inactive on β‐adrenoceptors, did not alter the increase in MAP produced by stimulation of the C 1 area. 4 The α 2 ‐adrenoceptor antagonist idazoxan enhanced the effects of C 1 stimulation on MAP when administered either into the posterior hypothalamus or intradsternally. 5 The results indicate that β 2 ‐ and α 2 ‐receptors both have a role in the mediation of the rise in MAP during stimulation of the C 1 area and that the receptors involved are located both within the hypothalamus and the spinal cord.