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The action of prostanoid receptor agonists and antagonists on smooth muscle and platelets
Author(s) -
Eglen R.M.,
Whiting R.L.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11565.x
Subject(s) - receptor , prostanoid , agonist , medicine , endocrinology , chemistry , carbachol , stimulation , prostaglandin , biology , pharmacology
1 Prostanoid receptors have been characterized in a range of guinea‐pig and rat smooth muscle and platelets, according to the scheme of Coleman et al ., (1985a), using agonists (prostaglandin D 2 (PGD 2 ), PGE 1 , PGE 2 , 16,16 dimethyl PGE 2 , PGF 2α , PGI 2 and U46619) and putative selective antagonists (AH 6809 and SQ 29,548). 2 The ileum possesses EP 1 ‐ and IP‐receptors; the trachea, EP 1 ‐EP 2 ‐ and TP‐receptors; the oesophageal muscularis mucosa, EP 1 ‐ and TP‐receptors; the aorta and the portal vein TP‐receptors. The rat colon possesses IP‐, FP‐ and TP‐receptors. 3 Guinea‐pig platelets possess both IP and DP receptors mediating an inhibition of aggregation and TP receptors mediating proaggregation responses. No evidence was found for the presence of EP 1 ‐, EP 2 ‐ or FP‐receptors. 4 Misoprostol and fenprostalene were characterized using the above preparations. Misoprostol acts as a selective EP 1 ‐agonist, and has little or no DP, FP, IP and TP activity. In the trachea precontracted with carbachol no evidence of EP 2 ‐receptor stimulation was observed. Fenprostalene possesses FP and TP activity but no EP 1 , EP 2 , DP or IP activity.