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Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats
Author(s) -
Durante William,
Sen Amar K.,
Sunahara Fred A.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11548.x
Subject(s) - sodium nitroprusside , phenylephrine , medicine , endothelium , endocrinology , acetylcholine , thoracic aorta , diabetes mellitus , adenosine , aorta , vasodilation , endothelium derived relaxing factor , calcium , chemistry , nitric oxide , blood pressure
1 Diabetes mellitus is known to produce alterations in vascular reactivity. The present study examined the effects of endothelium‐dependent and endothelium‐independent relaxing substances on thoracic aorta from control and spontaneously diabetic rats. 2 Endothelium‐dependent relaxation produced by acetylcholine or the calcium ionophore, A23817, in aortic rings precontracted with phenylephrine was significantly attenuated in diabetic vessels. 3 Relaxations produced by sodium nitroprusside or adenosine in diabetic preparations were comparable to those in control vessels. 4 The results show that diabetes leads to a specific impairment of endothelial‐dependent relaxation.