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Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro
Author(s) -
Kyle Helen,
Widdicombe J.G.,
Wilffert B.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11530.x
Subject(s) - methacholine , phenylephrine , salbutamol , contraction (grammar) , mucus , muscle contraction , endocrinology , medicine , in vitro , glycoprotein , chemistry , biology , biochemistry , asthma , respiratory disease , lung , ecology , blood pressure
1 The concentration‐response curves for rate of mucus output, labelled‐glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro . 2 The potencies of methacholine and phenylephrine are both in order: smooth muscle contraction, glycoprotein output, rate of mucus output. 3 At lower concentrations methacholine is more potent than is phenylephrine on smooth muscle contraction, glycoprotein output and rate of mucus output. 4 Concentration‐response curves for salbutamol show very little change in rate of mucus output but a large increase in glycoprotein output. 5 It is concluded that the glycoprotein output induced by salbutamol may come from a source different from those induced by methacholine and phenylephrine.