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Simultaneous release by bradykinin of substance P‐and calcitonin gene‐related peptide immunoreactivities from capsaicin‐sensitive structures in guinea‐pig heart
Author(s) -
Geppetti Pierangelo,
Maggi Carlo Alberto,
Perretti Francesca,
Frilli Stefania,
Manzini Stefano
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11528.x
Subject(s) - bradykinin , capsaicin , calcitonin gene related peptide , chronotropic , substance p , neuropeptide , medicine , endocrinology , guinea pig , chemistry , calcitonin , pharmacology , receptor , heart rate , blood pressure
Both bradykinin and capsaicin infusion evoked a marked increase in the outflow of substance P‐ (SP‐LI) and calcitonin gene‐related peptide‐like immunoreactivity (CGRP‐LI) from guinea‐pig isolated, perfused heart. After acute exposure to capsaicin in vitro , or in hearts taken from animals pretreated in vivo with capsaicin, bradykinin failed to induce any release. The positive chronotropic effect of bradykinin was reduced after acute capsaicin administration. The effect of bradykinin in the guinea‐pig heart could be mediated, at least partly, by release of neuropeptides from peripheral endings of capsaicin‐sensitive sensory neurones.