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Antihaemophilic effect of vasopressin, deamino‐( d ‐arginine 8 )‐vasopressin and adrenaline in sheep: proposal for an in vivo assay system
Author(s) -
Heiniger Jörg,
KisslingAlbrecht Luzia,
Neuenschwander Stefan,
Rösli Regula,
Pliška Vladimir
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11525.x
Subject(s) - vasopressin , arginine , in vivo , chemistry , endocrinology , medicine , arginine vasopressin receptor 1b , microgram , bioassay , in vitro , pharmacology , vasopressin receptor , biology , biochemistry , amino acid , microbiology and biotechnology , genetics
Female sheep were used to assay antihaemophilic (factor VIII enhancing) activity of arginine vasopressin, deamino‐( d ‐arginine 8 )‐vasopressin (DDAVP) and adrenaline. The time course of the response was biphasic, two surges of factor VIII being observed. DDAVP was found to be the most potent of the substances investigated. Its optimal dose was 1 μg kg −1 body wt (i.v.). It is suggested that a similar procedure can be employed to search for new peptides with antihaemophilic action.