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Vasodilator response to dopamine in the ferret pulmonary circulation
Author(s) -
Gorman P.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11517.x
Subject(s) - vasodilation , sulpiride , dopamine , agonist , medicine , endocrinology , dopamine agonist , dopamine receptor , dilator , chemistry , pharmacology , domperidone , receptor , dopaminergic
1 The isolated perfused lung of the ferret was used to study the effects of dopamine receptor agonists and antagonists. Under constant flow, a fall in pulmonary artery pressure reflects a vasodilator response. Since tone is normally low, agonists were given during hypoxic pulmonary vasoconstriction to enable detection of dilator responses. 2 Vasodilator responses were produced by bolus doses of dopamine over the range 0.1 to 5.0 μg kg −1 , and by the selective DA 1 agonist SK&F 38393 (1‐phenyl‐7,8‐dihydroxy‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepine hydrochloride). 3 The dopamine response was blocked by low doses of the selective DA 1 ‐antagonist SCH23390 (R‐(+)‐8‐chloro‐2,3,4,5‐tetrahydro‐3‐methyl‐5‐phenyl‐1H‐3‐benzazepine‐7‐ol maleate), and by sulpiride. 4 The vasodilator response to the relatively selective DA 2 ‐agonist N,N‐di‐n‐propyl dopamine occurred only at high dose and was incompletely blocked by the selective DA 2 antagonist domperidone at a cumulative dose of 10 mg kg −1 . 5 Thus dopamine receptors of the DA 1 type may mediate vasodilatation in the ferret pulmonary circulation, but no evidence was obtained for the existence of DA 2 ‐receptors.