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Blockade of vasopressor and vas deferens responses by α, β‐methylene ATP in the pithed rat
Author(s) -
Bulloch J.M.,
McGrath J.C.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11504.x
Subject(s) - vas deferens , purinergic receptor , stimulation , medicine , endocrinology , chemistry , adrenergic , norepinephrine , anesthesia , receptor , dopamine
1 The pressor responses produced by the intravenous administration of α,β‐methylene ATP were tachyphylactic. 2 α,β‐Methylene ATP can attenuate pressor responses to sympathetic nerve stimulation both in the presence and in the absence of α‐adrenoceptor blocking agents. 3 α,β‐Methylene ATP has no effect on the pressor responses produced by bolus injections of noradrenaline. 4 In the presence of α‐adrenoceptor blocking agents, α,β‐methylene ATP further attenuates contractions of the vas deferens produced by nerve stimulation. 5 The results, together with previous data, suggest that the vasopressor response to stimulation of the sympathetic outflow in the rat is partly purinergic and partly α‐adrenergic and that this occurs as co‐transmission. The same applies to rat vas deferens, confirming in vitro data. The pithed rabbit had an α‐blocker‐resistant vasopressor nerve‐mediated response but this was resistant to α,β‐methylene ATP.